Hence, it is conceivable which the JIP1/3???ASK1???MKK4 signaling module may well function a conduit to activate JNK when endosomal trafficking is disrupted and glucose concentrations slide over the early stages of methuosis. Our acquiring that MKK4 was robustly activated because of the methuosis-inducing IPPs, MOMIPP and 2q, and less so from the n